RESULTS CORDIAL-S

Performance parametres of the SPR-based COVID-19 sensing device

• Limit of detection= 10 pfu mL^-1 [corresponding to Ct=32.5 and 5.9x10^-4 to 1.9x10⁸ viral copies mL^-1]

• Same sensitivity fo different clades: 20A.EU2 (EU variant) | 20I/501Y.V1 (UK variant) | 20H/501Y.V2 (South African variant) | B.1.617.2+AY.1+AY.2 (Delta variant) | B.1.1.529 (Omicron variant)
• Validation on 200 nasopharyngeal samples by CHU Lille: 84 positive and 116 negative as identified by real-time polymerase chain reaction (RT-PCR) tests:

• 86% positive percentage agreement (PPA) as compared to the gold standard RT-qPCR

• 76% negative percentage agreement (NPA ) as compared to the gold standard RT-qPCR

• Integration of machine learning: recording of  1 min SPR sensogram data is sufficient to match the inferred results from 15 min sensing data.

Clinical Data availability

We strongly encourage any request for access to the full anonymized database of CorDial-S (Pr Szunerits, Pr Devos, Dr Rolland).
Please send the request to the following e-mail address  direction-recherchechu-lillefr

Publication related (Open acess format)

H. Saada, Q. pagneuc, J; Wei, L. Live, A. Roussel, A; Dogliani, L. Die Morini, I. Engelmann, E. K. Alidjinou, A. S. Rolland, E. Faure, J; Poissy, J. Labreuche, G. Lee, P. Li, G. Curran, A. Jahari, J. A. Yunda, S. Mlinte, A. Legay, J.-L. Gala, D. Devos, R. Boukehrroub, S. Szunerits
Sensing of COVID-19 spike protein in nasopharyngeal samples using a portable surface plasmon resonance diagnostic system
Sensors and Diagnostics 2022, 1, 1021
https://pubs.rsc.org/en/content/articlelanding/2022/sd/d2sd00087c

S. Szunerits, H. Saada, Q. Pagneux, R. Boukherroub
Plasmonic Approaches for the Detection of SARS-CoV-2 viral particles
Biosensors 2022, 12 (7), 548
https://www.mdpi.com/2079-6374/12/7/548